Jump to content

Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES)

From Wikipedia, the free encyclopedia
Heat shock protein 70 (Hsp70) IRES
Predicted secondary structure and sequence conservation of IRES_Hsp70
Identifiers
SymbolIRES_Hsp70
RfamRF00495
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) is an RNA element that allows cap independent translation during conditions such as heat shock and stress. It has been shown that the 216 nucleotide long 5' UTR contains internal ribosome entry site activity.[1]

References

[edit]
  1. ^ Rubtsova MP, Sizova DV, Dmitriev SE, Ivanov DS, Prassolov VS, Shatsky IN (June 2003). "Distinctive properties of the 5'-untranslated region of human hsp70 mRNA". The Journal of Biological Chemistry. 278 (25): 22350–22356. doi:10.1074/jbc.M303213200. PMID 12682055.
[edit]